[生化制药论文] 作者:张加雄,万丽, 胡轶娟 ,屈巧玲, 师健友
【关键词】 决明子;,,血脂;,,有效部位
摘要:目的研究决明子降血脂的有效部位。方法采用系统溶剂提取法对决明子进行分部位提取,制得决明子提取物。建立小鼠高脂血症模型,对各提取物进行降血脂药效学研究,确定决明子降血脂有效部位。结果决明子正丁醇提取物具有明显的降血脂作用,能显著降低高脂血症小鼠血清总胆固醇(TC)和甘油三酯(TG)。结论 正丁醇提取物为决明子降血脂有效部位。
关键词:决明子; 血脂; 有效部位
Study on the Effective Part of Reducing Blood Lipid in Semen Cassiae
Abstract:ObjectiveTo study the effective part of reducing blood lipid in Semen Cassiae.MethodsThe extracts of Semen Cassia were processed by dissolvent subsection-extracting, and then adopt hyperlipidemia model by mice to study the pharmacological effect of the different extracts from Semen Cassiae. ResultsThe n-BuOH extracts have obvious action of reducing blood lipid. It can notably lower total cholesterin (TC)and glycerinum( TG ) in serum from mice of hyperlipidemia.ConclusionnBuOH extracts is the active part of reducing blood lipid in Semen Cassiae.
Key words: Semen Cassiae; Blood Lipid; Effective Part 决明子为《中国药典》2005年版收载品种,为豆科植物决明Cassia obtusifolia L.或小决明Cassia tora L.的干燥成熟种子。性味甘、苦、咸,微寒。归肝、肾、大肠经。具有清肝明目,润肠通便的功效[1]。决明子具有确切的降血脂作用,近年来,决明子及其复方制剂在临床……
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