| [生化制药论文]
［摘要］ 目的:探讨P300检测对于评定脑卒中后合并抑郁患者认知功能障碍的价值。 方法 :用汉密切尔抑郁量表 (HAMD)测试 80例急性脑卒中患者 ,并将其分为抑郁组和非抑郁组,并设正常对照组60例，均经P300及HAMD检查。结果:抑郁组与非抑郁组 ,非抑郁组与正常对照组比较，P300潜伏期及波幅，HRSD评分差异均有显著性(P<0.01)。卒中后抑郁组患者P300潜伏期、波幅与其HAMD评分呈无显著相关性(P>0.05)。结论:P300检测可作为评定脑卒中合并抑郁患者认知功能的可靠手段。
［关键词］ 事件相关电位P300；脑卒中；抑郁；认知
The Clinical Study of Eventrelated Potential P300 for Poststroke Depression
Abstract: Objective To explore the clinical value of P300 in the evaluation of cognition for poststroke depression. Methods 80 acute stroke patients were assessed by Hamilton ,and then were divided into two groups:the depressive group and the undepressive group.,healthy control groups were selected. All objects were measured by P300 and the HAMD. Results There were significant differences in P300 peak latency ,amplitude and the HAMD score between the patients of depression or undepression and the controls respectively(P<0.01).In the group of poststroke depression ,the HAMD score have no significant correlation with the P300 peak latency and amplitude (P>0.05). Conclusion The results suggest that the P300 can be the reliable evaluative means of cognition for the poststroke depression.
Key words:Eventrelated potential;P300； Brain stroke；Depression；Cognition
脑卒中是危害老年人身体健康的严重疾病之一，卒中后抑郁(Poststroke depression,PS……
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