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大黄素对泼尼松致大鼠脂代谢异常的预防作用研究药学 |
| [生化制药论文]
【摘要】 目的观察不同浓度大黄素对泼尼松致大鼠脂代谢异常的预防作用。 方法 3月龄大鼠给予泼尼松和药物90 d。观察血清生化指标、器官指数和骨髓基质细胞体外的成脂能力。结果给予泼尼松和药物90 d后大鼠高密度脂蛋白胆固醇降低，骨髓基质细胞体外成脂能力增强。大黄素90 mg·kg- 1·d- 1和大黄素270 mg·kg- 1·d- 1可升高高密度脂蛋白胆固醇和骨髓基质细胞体外成脂能力。结论大黄素对泼尼松引起的脂代谢异常有预防作用。
【关键词】 大黄素 糖皮质激素 血脂 骨髓基质细胞 大鼠
Abstract:ObjectiveTo determine whether emodin can completely prevent dyslipidemia in rats treated with prednison. MethodsThirty-five Sprague-Dawley male rats at age of 3 months were divided into five groups and treated for 90 days as follows: intact rats were given with vehicle as control; Prednisone was given orally to the rats at dose of 3.0 mg/kg/d as the model group; Emodin at dose of 90mg/kg/d or 270 mg/kg/d were plus to the prednison treated rats and Integrated medicine (Calcium 375 mg/kg/d+VitD3 250 U/kg/d ) were plus to the prednison treated rats. The blood serum was separated for testing biochemistry indices. the MSCs were isolated by density-gradient centrifugation and cultured.ResultsRats treated with GC decreased serum HDL-Cholesterol and significantly increased serum sulfur compared with vehicle controls. Treatment with emodin markedly increased in the serum HDL-Cholesterol level and decreased serum sulfur. Emodin prevented adipogenic differentiation of MSCs from prednisone-treated rats.ConclusionEmodin shows effect of prevention against Glucocorticoid -induced dysl……
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| 投稿人：7uy |
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最后编辑：fibg |
生化制药论文 | 生化制药论文 |
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