| [高血压医学论文] 【关键词】 STZ大鼠；,糖尿病视网膜病变；,缺氧诱导因子；,血管内皮细胞生长因子
Expressions of hypoxiainducible factor1α and vascular endothelial growth factor in retina of streptozotocininduced diabetic rats
【Abstract】 AIM: To study the expressions of hypoxiainducible factor1α (HIF1α) and vascular endothelial growth factor (VEGF) in retina of streptozotocininduced diabetic rats. METHODS: Sixty Wister rats were divided into testing group (group T, 45 cases) and control group (group C, 15 cases). Streptozotocininduced diabetic animal models were made in group T, and then the rats were divided into 3 groups ( T1, T3, T5) according to the time (1, 3, 5 months) after modeling. The rats in group C were also divided into 3 groups (C1, C3, C5). The expression of VEGF was assessed by immunohistochemical method and the expression of HIF1α was assessed by Western Blotting. All the results were quantitatively analyzed by transformed into average optical density. RESULTS: 86.67%-93.33% of all the animal models were successful. Results of VEGF: There were no significant difference in the 3 control groups, as well as between group T1 and control groups (P>0.05); But the significant difference was found between group T3, T5 (t=6.12, P<0.01) and control groups (t=8.63, P<0.01) as well as between group T3 and T5 (t=3.45, P<0.05). Results of HIF1α: There was no significant difference in the 3 control groups and in the 3 testing groups (P>0.05). But the significant differences were found between group T1, T3, T5 and the 3 c……
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