[中医学论文]
【摘要】目的 探讨格列吡嗪联合吡格列酮对2型糖尿病疗效的影响。方法 选取2010年7月-2011年6月门诊治疗的2型糖尿病病人112例，随机分为观察组和对照组，观察组给予格列吡嗪联合吡格列酮治疗，对照组单纯给予格列吡嗪治疗。观察治疗12周后前后空腹血糖(FPG)、餐后2h血糖(2hPG)和糖化血红蛋白(HbA1C)的情况及其有无不良反应。结果 治疗12周后FPG，2hPG、HbA1C均有明显下降，观察组疗效明显优于对照组(P<0.05)。结论 格列吡嗪联合吡格列酮有协同控制血糖的作用，且不良反应轻微，安全性、依从性良好。
【关键词】 格列吡嗪 吡格列酮 2型糖尿病 疗效
【Abstract】 Objective Investigate glipizide combined with pioglitazone in type 2 diabetes mellitus curative effect.Methods from 2010 January - 2011 January outpatient treatment in type 2 diabetic patients 112 cases, were randomly divided into the observation group and the control group, the observation group give glipizide combined with pioglitazone treatment, the control group only received glipizide therapy. Observation of treatment for 12 weeks before and after fasting blood glucose (FPG), 2h postprandial plasma glucose (2hPG) and glycosylated hemoglobin (HbA1C) condition and have no adverse reaction. results for 12 weeks after FPG, 2hPG, HbA1C were significantly decreased, the observation group was better than control group (P<0.05). Conclusion glipizide combined with pioglitazone have a synergistic role of glycemic control, and mild adverse reaction, safety, compliance is good.
【Key words】glipizide pioglitazone type 2 diabetes curative effect
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