作者：周丽华，徐礼鲜，张惠，李源，徐瑞芬，王惠霞，刘春然

【关键词】  浓度

    Effect of continuously infused propofol of different concentrations on serum lipid metabolism in rabbits

      【Abstract】  AIM: To observe the pharmacodynamics of 50 g/L propofol and its effect on the serum lipid metabolism of rabbits. METHODS:  Twelve rabbits of both sexes were randomized  into 2 groups. All rabbits received 6 mg/kg bolus doses at a speed of 0.6 mg/s of 10 g/L and 50 g/L propofol from a marginal ear vein, the effect onset time was recorded. Propofol was then administered under computer control for 360 min at a speed of 400 μg/(kg・min) . The heart rate, blood pressure and respiration rate were measured during the infusion, and the recovery time was recorded. Arterial blood samples were collected before infusion and 5, 30, 60, 180, 360 and 365 min after infusion for the measurement of blood propofol concentrations and the serum concentrations of triglyceride, cholesterol, highdensity lipoprotein cholesterol and lowdensity lipoprotein cholesterol. RESULTS:  The effect onset time and the blood propofol concentrations at different time points had no statistical differenc……