作者：宋力，崔小健，苏大军，谭国良

【关键词】  前列腺肿瘤；基因；EZH2

　　Expression profile and significance of EZH2 gene in primary prostate cance

　　【Abstract】 AIM: To determine the expression of EZH2 gene in prostate cancer （PCa） and to investigate the relation between EZH2 expression and biological characters of PCa. METHODS: In 40 cases of PCa, 20 cases of benign prostate hyperplasia (BPH), 20 cases of prostatic intraepithelial neoplasia (PIN), the expression of EZH2 was detected by semiquantitative RTPCR and the amplified product was sequenced. RESULTS: All 40 PCa cases were positive in EZH2 expression. The re was no expression of EZH2 gene in BPH. Only one of the 20 PIN cases was seen EZH2 expressed positively. EZH2 expression was increased in the advanced compared with the primary PCa (P＜0.05), in the lowdifferentiated compared with the highlydifferentiated PCa (P＜0.05) and in the hormonedependent compared with the hormoneindependent PCa (P＜0.05). However , EZH2 expression did not have a linear correlation with the serum total prostate specific antigen level (P＞0.05). CONCLUSION: EZH2 gene plays an important role in the development of prostaic carcinoma. Therefore, the analysis of EZH2 expression will benefit the diagnosis and treatment of prostatic carcinoma.

　　【Keywords】 prostatic carcinoma; gene; EZH2

　　【摘要】 目的：探讨EZH2基因在列腺癌组织中的表达意义. 方法 ：采用半定量RT－PCR检测前列腺癌、前列腺上皮内瘤(PIN)，……