【摘要】  目的：探讨肺表面活性物质（PS）早期给药对极低出生体重儿呼吸窘迫综合征（NRDS）疗效的观察。方法：对19例患NRDS的极低出生体重儿给予PS治疗并同时进行临床对照实验。结果：NRDS患儿给药后２４h PO2/FiO2较用药前明显改善，差异显著（P<0.05），呼吸机参数（除ＰＥＥＰ外）明显下降，差异有显著性意义（P<0.05）。结论：对于极低出生体重儿NRDS，早期给予PS治疗可明显改善近期预后，提高存活率。

【关键词】  肺表面活性物质；呼吸窘迫综合征；极低出生体重

　　Observing the Effect of Pulmonary Surfactant Early Bringing
    Down Neonatal Respiratry Distress Syndrome

　　Abstract: Objective： To explorei effect of pulmonary surfactant (PS) in the treatment of neonatal respiratry dstress syndrome (NRDS) in early phase. Method：19 examples low birth weight infants with NRDS were treated with pulmonary surfactant in this controlled clinical trail. Result：After given PS 24 hours,the PO2/FiO2 and parameter of  respirator utilization ascended significantly, there were significant difference ( P<0.05).Conclusion： The strategy of surfactant treatment in early phase can significantly improve the survival of very low birth weight infants with NRDS .

　　Key words:  Pulmonary Surfactant；  Neonatal respiratory distress syndrome；Born very low birth infant     &n……