作者：刘静 王恒湘 段连宁 薛梅 朱玲 阎洪敏 丁丽 纪树荃

【摘要】  本研究观察小剂量抗胸腺细胞球蛋白（ATG）在对激素耐药的重度急性移植物抗宿主病（aGVHD）治疗中的作用。对6例单倍相合骨髓移植后出现激素耐药的重度aGVHD的患者给予小剂量ATG 1.25 mg/kg治疗，隔日1次，共3-5剂。结果显示， 完全缓解3例，其中2例无病生存，1例死于白血病复发；另3例中1例部分缓解，2例病情恶化，这3例患者均死于GVHD。应用小剂量ATG治疗的总有效率66.67%，长期生存率33.33%，感染是其主要并发症。结论：小剂量ATG对部分激素耐药的重度aGVHD有一定疗效，且无严重毒副作用，加强洁净环境保护以预防感染也颇为重要。

【关键词】  骨髓移植

     Antithymocyte Globulin Used for Treatment of Severe Acute Graft Versus Host Disease after Haploidentical Bone Marrow Transplantation

      Abstract    The objective of study was to investigate  the effect of lowdose antithymocyte globulin (ATG) on  steroidresistant severe acute graft versus host disease (aGVHD). Six patients with steroidresistant severe aGVHD after haploidentical bone marrow transplantation (BMT) received the treatment with ATG at a low dose of 1.25 mg/kg for 3-5 doses every other day. The results showed that 3  out of 6 patients  got completely remission (CR), among them 2 patients  have  still been in diseasefree survival, 1 patient  died from leukemia relapse. 1  out of the other 3 patients got partial remissin (PR), 2 patients were aggravated. The other……

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