【摘要】  目的： 探索伊曲康唑治疗儿童白癣的优化方案. 方法： 93例明确诊断的白癣患儿随机分为2组. 治疗组51例，给予伊曲康唑胶囊冲击疗法： 5 mg/kg，口服，1次/d，服药1 wk，停药1 wk，同时给予30 g/L碘酊，涂患处，2次/d，50 g/L水杨酸软膏与50 g/L硫磺软膏等量混合后涂患处，2次/d，4 wk为1个疗程；对照组42例，给予伊曲康唑胶囊连续疗法： 5 mg/kg，1次/d，外用药同治疗组，4 wk为1个疗程. 治疗结束后每2 wk随访1次，每次随访时进行真菌镜检、培养，至治疗结束后6 mo，对于随访过程中真菌学阳性的患儿，按原治疗方案继续服药2 wk. 结果： 在服药4 wk时，临床及真菌学痊愈（率）： 治疗组49例（96.08%），对照组41例（97.62％），二者之间无统计学差异(P>0.05). 治疗组2 (3.92%)例患儿出现不良反应，对照组为5 (11.90%)例, 其发病率明显高于治疗组(P<0.05). 结论： 伊曲康唑治疗儿童白癣安全、有效、疗程短；冲击疗法比连续疗法更经济.

【关键词】  白癣；冲击疗法；伊曲康唑

　　【Abstract】 AIM: To explore the optimum regimen for tinea capitis of childhood with itraconazole. METHODS: A prospective, randomized, open parallel controlled clinical trial was conducted. A total of 93 cases of tinea capitis of childhood were divided into 2 groups. Itraconazole capsules 5 mg/kg·d were given orally once every day for every other week in pulse therapy group (n=51) and every day in continuous therapy group (n=42), with 4 weeks as a course of treatment. Concomitant topical therapy was composed of 30 g/L iodine lotion used twice daily, and equivalent admixture of 50 g/L salicylic ointment and 50 g/L sulphur ointment used twice daily. The followup was conducted every 2 weeks for mycological ……