【摘要】  目的：比较腹腔镜手术与传统开腹手术对患者免疫机能的影响。方法：2006年12月至2007年7月收治结直肠癌患者60例，分别行腹腔镜手术和开腹手术各30例，于术前1d和术后第3天、第7天抽取外周静脉血,比较两组患者的C反应蛋白，IgA,IgM,IgG,IL6,CD3+,CD4+,CD8+细胞和NK细胞，比较术前1d和术后第1天、第3天TNFα细胞活性。结果：术后第3天患者CD3+,CD4+,CD8+细胞活性及CD4+/CD8+差异无显著性，但术后第7天腹腔镜较开腹组明显低。术后第3天IL6开腹组明显高于腹腔镜组。C反应蛋白于术后第3天开腹组高于腹腔镜组。IgM于术后第3天开腹组高于腹腔镜组，IgA、IgG无显著统计学意义。TNFα于术后第3天开腹组高于腹腔镜组。结论：腹腔镜结直肠癌根治术较传统开腹手术对机体免疫机能影响较小。

【关键词】  结直肠肿瘤；腹腔镜术；免疫测定

    The comparison of effects of laparoscopic radical operation and open operation on immune system YANG Shuo,ZHANG Jianli.Dept.of General Surgery,the Affiliated Hospital of Qingdao University,Qingdao 266021,China

    【Abstract】  Ｏbjective:To compare the influence of laparoscopic radical operation and open operation on systematic immunity in patients with colorectal carcinoma.Methods:Collecting sixty patients with colorectal carcinoma from Nov.2006 to Jul.2007,the patients were randomly divided into two groups(laparoscopic operation and open operation),each group with 30 cases.NK cell,IgA,IgM,IgG,IL6,IL8,CD3+,CD4+,CD8+ in peripheral blood were counted and compared on the 1st day before operation,the 3rd and 7th day after operation.TNFα in peripheral blood was counted and……